Capillary Permeability to Macromolecules

Capillary permeability to macromolecules.

Lysophosphatidylcholine increases rat ileal permeability to macromolecules.

The influence of lysophosphatidylcholine (LPC) on macromolecular permeability in the distal ileum has been studied. Using a rat experimental model, we determined the intestinal permeability to different sized dextrans (3000-70 000 daltons) and bovine serum albumin (BSA) in the absence and presence of LPC. We also examined the morphology of the ileal mucosa after deposition of LPC in the gut lum...

Capillary Permeability to Plasma Proteins.

ACCORDING to the classical hypothesis of Starling (1896) the exchange of water and small lipid-insoluble molecules across the capillary membrane is largely governed by the balance between hydrostatic and colloid osmotic pressures, the existence of the latter being dependent upon relative impermeability of the capillary membrane to plasma proteins. Starling's concept has been verified by direct ...

Enhanced glomerular permeability to macromolecules in the Nagase analbuminemic rat.

Plasma albumin restricts capillary water filtration. Accordingly, the glomerular ultrafiltration coefficient is higher in Nagase analbuminemic rats (NAR) than in Sprague-Dawley controls. We investigated whether the glomerular permeability to macromolecules is also enhanced in NAR. SDS-PAGE fractionation of urine proteins showed several bands with molecular masses between 60 and 90 kDa in NAR on...

Glomerular permeability to macromolecules in the Necturus kidney.

Many aspects of the glomerular filtration of macromolecules remain controversial, including the location of the major filtration barrier, the effects of electrical charge, and the reason the filtration barrier does not clog. We examined these issues in anesthetized Necturus maculosus, using fluorescently labeled probes and a two-photon microscope. With the high resolution of this system and the...